Keratolytic winter erythema, also known as Oudtshoorn skin disease, is a monogenic autosomal dominant, highly penetrant genodermatosis of seasonal desquamation of the palms and soles. Originally described in a cohort in South Africa,1,2 it has subsequently been identified in a large pedigree of German origin.3 The disease locus has been mapped to chromosome 8p22-p23.3 We report a case that was clinically and histologically indistinct from Oudtshoorn skin disease but was unlinked to this region.
Huntington MK, Jassim AD. Genetic Heterogeneity in Keratolytic Winter Erythema (Oudtshoorn Skin Disease). Arch Dermatol. 2006;142(8):1065–1086. doi:10.1001/archderm.142.8.1073
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: