Microscopic examination of the biopsy specimen revealed an infiltrative and cellular proliferation of atypical endothelial cells, with formation of irregular vascular lumina. Tissue cultures were negative for bacterial and fungal pathogens. After the diagnosis of high-grade angiosarcoma was made, the patient underwent a staging workup, consisting of computed tomography of the head, neck, trunk, and pelvis. There was no evidence of either local invasion into the frontal bone or distant metastatic disease.
Fungating Forehead Plaque—Diagnosis. Arch Dermatol. 2006;142(8):1059–1064. doi:10.1001/archderm.142.8.1059-e