A Case of CD56+ Mycosis Fungoides

Mycosis fungoides (MF) is a form of cutaneous T-cell lymphoma in which the neoplastic cells are epidermotropic CD3⁺, CD4⁺, CD8⁻, CD45RO⁺, and CD56⁻ mature memory T cells. The disease generally follows an indolent course.^1,2 In contrast, the CD56⁺ cutaneous lymphomas reported in the literature generally do not present like MF and have an aggressive disease course with a poor prognosis.^3,4 We describe a patient with a clinical presentation and course consistent with MF in whom the neoplastic cells were CD2⁺, CD3⁺, CD4⁻, CD8⁻, and CD56⁺.