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November 2006

Long-term Control of Papular Dermatitis (“Dermal Hypersensitivity Reaction”) With Mycophenolate Mofetil

Arch Dermatol. 2006;142(11):1508-1518. doi:10.1001/archderm.142.11.1512

In dermatology practice, patients frequently present with a recalcitrant eruption distinguished by the presence of edematous, urticarial, intensely pruritic papules. After analysis of patient biopsy specimens, the dermatopathologist will often report a “dermal hypersensitivity reaction” (DHR) characterized by an eosinophil-rich infiltrate. The only clinical differentials that correspond to this pathologic diagnosis are arthropod bite and drug eruption, neither of which is clinically relevant to the present case.