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December 2006

Unilateral Aquagenic Wrinkling of the Palms Associated With Aspirin Intake

Arch Dermatol. 2006;142(12):1650-1666. doi:10.1001/archderm.142.12.1661

Aquagenic wrinkling of the palms (AWP) is an uncommon condition characterized by the development of transient, white, edematous plaques on the palms after brief exposure to water. While most case reports associate this finding with cystic fibrosis, AWP has also been described as an idiopathic phenomenon1 and in association with marasmus2 and with rofecoxib exposure.3 In a recent publication, Katz et al4 reported marked AWP in 2 patients with cystic fibrosis due to homozygous ΔF508 mutations in the cystic fibrosis transmembrane regulator gene (CFTR). Herein, we describe a patient who developed AWP in close temporal association with aspirin intake.