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Comments and Opinions
February 2007

Rebound Vasodilation From Long-term Topical Corticosteroid Use

Author Affiliations

Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Dermatol. 2007;143(2):264-276. doi:10.1001/archderm.143.2.268-b

The Cutting Edge article “Successful Treatment of Severe Atopic Dermatitis in a Child and an Adult With the T-Cell Modulator Efalizumab”1 in the May 2006 issue of the ARCHIVES discusses another medication for this disease with both short- and long-term potential for toxic effects added to the panoply of similar medications, including azathioprine, mycophenolate, cyclosporine, and other immunomodulators. As yet unknown adverse effects of efalizumab might preclude its long-term use. I suggest another approach to the “problem” of atopy before instituting treatments with new medications.