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Off-Center Fold
April 2007

Erythema and Blistering of the Left Leg—Diagnosis

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Arch Dermatol. 2007;143(4):535-540. doi:10.1001/archderm.143.4.536-c

Histopathologic examination of the biopsy specimen showed vacuolar degeneration of basal cells and necrotic keratinocytes sandwiched between orthokeratotic stratum corneum and regenerating epithelium of the lower epidermis. In the dermis, edema and extravasated erythrocytes as well as a superficial and deep mixed inflammatory infiltrate with some eosinophils were observed (Figure 2).

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