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January 2008

Delayed Diagnosis of Cutaneous Rosai-Dorfman Disease With Distinctive Histologic Features in a Malayan Man

Arch Dermatol. 2008;144(1):120-121. doi:10.1001/archdermatol.2007.19

Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease (RDD), is classically seen in a young male patient who presents with bilateral cervical lymphadenopathy and fever.1,2 Extranodal involvement occurs in about 40% of reported cases, usually in association with nodal disease.3 Purely cutaneous RDD, although rare, appears to be more common in the Asian population.4,5 However, without the accompanying lymphadenopathy, cutaneous presentation is nonspecific, and diagnosis is dependent on histologic findings. Herein we describe an Asian patient with characteristic but nonspecific skin lesions whose diagnosis of cutaneous RDD was delayed in the presence of distinctive histologic features.