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Off-Center Fold
January 2008

Erythematous Pedunculated Papule on a 29-Year-Old Man—Diagonosis

Author Affiliations


Arch Dermatol. 2008;144(1):105-110. doi:10.1001/archdermatol.2007.10-b

Hematoxylin-eosin–stained sections showed a relatively well-circumscribed dermal proliferation of epithelioid cells with eosinophilic, slightly “foamy” cytoplasm. Isolated mitotic figures were observed. An extensive panel of immunostains revealed no significant staining with CD31, actin, epithelial membrane antigen, pancytokeratin, HMB-45, or Mart-1. MIB-1 showed a mildly increased proliferative index, and S100 protein highlighted dermal dendritic cells incorporated within the lesion. Many of the lesional cells were positive for CD68.