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January 2008

Recurrent Pustular Eruption in an Infant—Diagnosis

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Arch Dermatol. 2008;144(1):105-110. doi:10.1001/archdermatol.2007.13-b

Histopathologic examination of a pustular lesion revealed a hair follicle that had been partially destroyed by an intense mixed inflammatory infiltrate. The infiltrate, which was mainly composed of eosinophilic leukocytes, extended to the perifollicular area. The patient had leukocytosis, with prominent peripheral eosinophilia. Total and specific serum IgE levels were within normal limits. Swabs for bacteriologic and mycologic cultures failed to yield any organisms, and scrapings were negative for scabies. The patient was diagnosed as having infantile EPF. After the biopsy, a rapid, spontaneous resolution occurred a few days later, and no recurrence has been noted in 11 months of follow-up.

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