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February 1, 2008

Solitary Nodule on the Thigh—Diagnosis

Author Affiliations

Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Dermatol. 2008;144(2):255-260. doi:10.1001/archdermatol.2007.40-b

Histologic examination of the biopsy specimen revealed multiple islands of basaloid cells within the reticular dermis and subcutaneous fat. The islands were round, oval, or occasionally angular and were surrounded by a fibrotic stroma. No connection to the overlying epidermis was observed. Areas of peripheral palisading were noted as well as some centrally located larger pale epithelial cells, but the most striking feature was the presence of numerous lymphocytes within each island. Stromal-epithelial clefts and atypical mitotic figures were absent. A few ducts were observed in some of the tumor islands.