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May 1, 2008

Symmetrical Reddish Swelling of the Eyebrows in a 12-Year-Old Girl—Quiz Case

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Arch Dermatol. 2008;144(5):673-678. doi:10.1001/archderm.144.5.673-c

A 12-year-old girl presented with a 3-month history of symmetrical swellings of her eyebrows. She was otherwise healthy and did not take any medication. Physical examination revealed on the medial part of both eyebrows a painless, ill-defined, reddish nodule, associated with reduced hair growth (thinner hairs, but no alopecia) (Figure 1). Regional lymph nodes were unremarkable. The differential diagnosis included follicular mucinosis, ulerythema ophryogenes, pseudolymphoma, sarcoidosis, facial eosinophilic granuloma, and lupus erythematosus (tumid type). Laboratory test results, including red and white blood cell counts, transaminases, electrophoresis, antinuclear antibodies, anticardiolipin antibodies, lupus anticoagulant, serum complement (factors C3 and C4), and angiotensin-converting enzyme, were within reference range. Two biopsy samples were taken and stained with hematoxylin-eosin (Figure 2 and Figure 3) as well as with a panel of immunohistochemical markers.

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