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June 1, 2008

Contact Dermatitis to Pentylene Glycol in a Prescription Cream for Atopic Dermatitis: Case Report

Arch Dermatol. 2008;144(6):810-812. doi:10.1001/archderm.144.6.810

According to the package insert, MimyX Cream (Stiefel Laboratories Inc, Coral Gables, Florida) is a “fragrance-free, preservative-free, water-based emulsion formulated for the management and relief of the burning and itching experienced with various types of dermatoses, including atopic dermatitis, allergic contact dermatitis and radiation dermatitis.”1 The MimyX Cream package label lists the following ingredients: purified water, olive oil, glycerin, pentylene glycol (PTG), palm glycerides, vegetable oil, hydrogenated lecithin, squalane, betaine, palmitamide monoethanolamine (PEA), sarcosine, acetamide monoethanolamine, hydroxyethyl cellulose, sodium carbomer, carbomer, and xanthan gum.1 The PEA is an endogenous bioactive fatty acid that is deficient in atopic skin and is reported to be replenished by MimyX Cream.2 The cream is also said to restore the disrupted skin barrier characteristic of atopic dermatitis.2

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