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August 18, 2008

Therapeutic Effect of Argatroban on Rheumatoid Vasculitis With Antiphosphatidylserine-Prothrombin Complex Antibody

Arch Dermatol. 2008;144(8):1075-1076. doi:10.1001/archderm.144.8.1075

Rheumatoid vasculitis (RV) is an inflammatory condition of the small and medium-sized vessels that affects a subset of patients with established rheumatoid arthritis (RA). Detection of antiphospholipid cofactor antibodies including antiphosphatidylserine-prothrombin complex (aPS/PT) antibodies in addition to the classic anticardiolipin antibodies and lupus anticoagulant (LAC) seems to be of considerable clinical importance.1 Argatroban is a synthetic monovalent direct anticoagulant and thrombin inhibitor.2