Saida et al highlight a potentially important quandary concerning the histopathologic characteristics of melanocytic nevi situated along the Wallace line. This demarcation line delineates glabrous from nonglabrous skin. Saida et al, based on their experience and observations, conclude that some clinically and presumably biologically benign nevi located along the Wallace line may reveal histopathologic features commonly associated with melanoma. Although Saida1 originally agreed with our diagnosis of melanoma,2 he and his colleagues are now of a different opinion. This amended opinion is based on newly gained insights from a study Saida and coworkers have undertaken to evaluate the histologic characteristics of acral nevi located along the Wallace line (unpublished data). As a consequence of this new insight, Saida et al suggest that our case2 may in fact represent a pseudomelanoma lesion because it shows benign clinical and dermoscopic features while manifesting histologic features mimicking melanoma.
Marghoob AA, Braun RP. Anatomic Transitions and the Histopathologic Features of Melanocytic Nevi—Reply. Arch Dermatol. 2008;144(9):1233–1234. doi:10.1001/archderm.144.9.1233