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October 20, 2008

Imatinib-Induced Hand-Foot Syndrome in a Patient With Metastatic Gastrointestinal Stromal Tumor

Arch Dermatol. 2008;144(10):1400-1402. doi:10.1001/archderm.144.10.1400

Imatinib has become a main chemotherapeutic agent, especially for metastatic gastrointestinal stromal tumors (GISTs) and chronic myeloid leukemia. To our knowledge, we report herein the first case of hand-foot syndrome induced by this drug.

A 49-year-old man with no known medical history was diagnosed as having metastatic GIST in July 2006. A computed tomographic scan revealed large bilobar hepatic nodules, and upper digestive endoscopy revealed a 3-cm ulcerated submucosal lesion of the antrum having a gross aspect consistent with GIST. Biopsy confirmed the diagnosis of malignant GIST with a high expression of CD117.

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