MARY S.STONEMDSOONBAHRAMIMDCARRIE ANN R.CUSACKMDSENAIT W.DYSONMDMOLLY A.HINSHAWMDVINCENTLIUMD
Histologic examination revealed an acanthotic epidermis with an underlying well-circumscribed vascular proliferation extending from the papillary dermis to the base of the biopsy specimen. The vascular proliferation consisted of solid sheets of large polygonal epithelioid cells containing abundant eosinophilic cytoplasm and vesicular nuclei as well as open vascular channels lined by a single layer of variably epithelioid-appearing endothelium. The epithelioid-appearing cells, composing the solid areas, demonstrated prominent intracytoplasmic vacuoles forming microlumina. Cytologic atypia was absent, and only rare typical-appearing mitotic figures were present. The adjacent dermis contained a mild chronic inflammatory infiltrate of lymphocytes, plasma cells, and histiocytes. Eosinophils and lymphoid follicles were absent. The epithelioid cells were positive for the endothelial marker CD31.
Solitary Erythematous Nodule on the Back—Diagnosis. Arch Dermatol. 2010;146(4):439–444. doi:10.1001/archdermatol.2010.40-b
Dermatology in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.