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September 2010

Failed Treatment of Amelanotic Lentigo Maligna With Imiquimod Followed by Pigment Production

Author Affiliations

Author Affiliations: Case Western Reserve School of Medicine Department of Dermatology, University Hospitals Case Medical Center, Cleveland, Ohio (Ms Martires and Dr Bordeaux); Roger Williams Medical Center, Providence, Rhode Island (Dr Capaldi); Dermatology Associates of Wisconsin, Manitowoc (Dr Pattee); and University of Massachusetts School of Medicine, Worcester (Dr Maloney).

Arch Dermatol. 2010;146(9):1047-1048. doi:10.1001/archdermatol.2010.237

A melanotic lentigo maligna (ALM) represents a small subset of lentigo maligna (LM) that lacks pigment. At least 2 cases of ALM responsive to imiquimod therapy with short-term follow-up have been reported.1 We report herein a case of ALM that failed to respond to imiquimod treatment. Furthermore, after therapy was initiated, the ALM began to produce pigment and transformed to LM.

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