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December 2010

HLA-B*1502 Allele Associated With Carbamazepine-Induced Epidermal Necrolysis

Author Affiliations

Author Affiliations: Indiana University School of Medicine (Ms Odueyungbo), Department of Dermatology (Drs Sheehan and Haggstrom), Indianapolis.

Arch Dermatol. 2010;146(12):1437-1438. doi:10.1001/archdermatol.2010.364

Epidermal necrolysis (Stevens-Johnson syndrome [SJS] and toxic epidermal necrolysis [TEN]) is a rare, drug-induced, acute, and potentially life-threatening mucocutaneous reaction. Antiseizure medications are frequently implicated. Recently, a strong association was found between HLA-B*1502 and carbamazepine-induced epidermal necrolysis in the Han Chinese population.1 Rare reports recommend genotyping all Asian patients before initiating carbamazepine treatment.2 The present report describes an Asian teenage boy with HLA-B*1502 who developed TEN while being treated with carbamazepine.

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