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April 2011

Angiolymphoid Hyperplasia With Eosinophilia Revisited: Lack of Durable Response to Intralesional Interferon Alfa-2a

Author Affiliations

Author Affiliations: Dermatology Service, Walter Reed Army Medical Center, Washington, DC.

Arch Dermatol. 2011;147(4):507-508. doi:10.1001/archdermatol.2011.69

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular disorder of unknown pathogenesis that has a predilection for young white women. It usually presents as pink to red-brown, dome-shaped, dermal papules or nodules of the head and neck, most often in the periauricular area. Symptoms may include pain, pruritus, and spontaneous bleeding after minor trauma. Histologically, ALHE demonstrates a proliferation of thick-walled vessels with prominent endothelial cells (hobnailing) as well as an infiltration of lymphocytes and eosinophils.1 Multiple treatments have been reported, including intralesional injection with interferon alfa-2a, surgery, and various lasers including argon, carbon dioxide, and pulsed dye.2