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April 2011

Bilateral Areolar Lesions in a Patient With Acute Cutaneous Graft-vs-Host Disease

Author Affiliations

Author Affiliations: Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (Drs Brunengraber and Stratton), Dermatology Branch, National Cancer Institute (Dr Turner), and Laboratory of Pathology, National Cancer Institute (Dr Lee), National Institutes of Health (NIH), Bethesda, Maryland.

Arch Dermatol. 2011;147(4):509-511. doi:10.1001/archdermatol.2011.75

A 34-year-old woman for whom chemotherapy had failed to cure acute lymphocytic leukemia received an allogeneic hematopoietic stem-cell transplant (HSCT) that was complicated by biopsy-proven, acute, generalized, cutaneous graft-vs-host disease (GVHD) beginning 39 days after transplant. She was referred for an obstetric and gynecologic evaluation on day 58 for nipple cracking and dryness of 3 weeks' duration. She denied breastfeeding, exposure of the nipples to any topical or mechanical irritants, or sun exposure. Her generalized skin eruption had resolved by this time.