A 34-year-old woman for whom chemotherapy had failed to cure acute lymphocytic leukemia received an allogeneic hematopoietic stem-cell transplant (HSCT) that was complicated by biopsy-proven, acute, generalized, cutaneous graft-vs-host disease (GVHD) beginning 39 days after transplant. She was referred for an obstetric and gynecologic evaluation on day 58 for nipple cracking and dryness of 3 weeks' duration. She denied breastfeeding, exposure of the nipples to any topical or mechanical irritants, or sun exposure. Her generalized skin eruption had resolved by this time.