Isotretinoin Therapy and Inflammatory Bowel Disease

Crockett SD, Gulati A, Sandler RS, Kappelman D

Am J Gastroenterol. 2009;104(10):2387-2393.

Question: Is oral isotretinoin use associated with the development of inflammatory bowel disease (IBD)?

Design: Critical appraisal of published case reports and case series using the Hill criteria for causality.

Data Sources: Data were obtained from a systematic search of published case reports and case series.