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Evidence-Based Dermatology: Research Commentary
January 17, 2011

Effectiveness of Oral Ivermectin and Malathion Lotion for Difficult-to-Treat Head Lice

Arch Dermatol. 2011;147(1):98-100. doi:10.1001/archdermatol.2010.400

Chosidow O, Giraudeau B, Cottrell J, et al

N Engl J Med. 2010;362(10):896-905

Question: In patients with difficult-to-treat head lice, is oral ivermectin more effective than topical malathion lotion?

Design: Multicenter, cluster-randomized, double-blind, double-dummy, active-controlled trial.

Setting: Community-recruited patients from 7 study centers (4 in the United Kingdom and 1 each in Ireland, France, and Israel) by means of advertising or outreach by nurses.

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