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February 2011

Multiple Primary Cutaneous Melanomas in Li-Fraumeni Syndrome

Author Affiliations

Author Affiliations: Section of Dermatology (Dr Curiel-Lewandrowski), Department of Surgery (Dr Warneke), The Skin Cancer Institute and Cutaneous Oncology Program (Drs Curiel-Lewandrowski, Cranmer, Warneke, and Loescher) and Section of Hematology and Oncology (Dr Cranmer) at the Arizona Cancer Center, and College of Nursing (Dr Loescher), University of Arizona, Tucson; and Department of Dermatology, Mayo Clinic Arizona, Tucson (Dr Speetzen).

Arch Dermatol. 2011;147(2):248-250. doi:10.1001/archdermatol.2010.428

Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant cancer syndrome characterized by early-age onset of multiple primary tumors—primarily soft tissue and bone sarcomas, breast cancer, brain tumors, and adrenocortical carcinomas—affecting individuals and multiple family members1 with germline p53 mutations occurring in 50% to 70% of families.2 Melanoma is a rare, controversial component of LFS.