Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant cancer syndrome characterized by early-age onset of multiple primary tumors—primarily soft tissue and bone sarcomas, breast cancer, brain tumors, and adrenocortical carcinomas—affecting individuals and multiple family members1 with germline p53 mutations occurring in 50% to 70% of families.2 Melanoma is a rare, controversial component of LFS.
Curiel-Lewandrowski C, Speetzen LS, Cranmer L, Warneke JA, Loescher LJ. Multiple Primary Cutaneous Melanomas in Li-Fraumeni Syndrome. Arch Dermatol. 2011;147(2):248–250. doi:10.1001/archdermatol.2010.428
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