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February 1999

Cutaneous Clues to Cronkhite-Canada Syndrome: A Case Report

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Arch Dermatol. 1999;135(2):212. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-2-dlt0299

Cronkhite-Canada syndrome is a rare, noninherited disorder of intestinal polyposis with onychodystrophy, hyperpigmentation, and alopecia.1 We report an unusual case that developed after a blistering eruption.

A 68-year-old man presented with weight loss of 18 kg over 7 months, nail changes, alopecia, and hyperpigmentation. Initially, the patient experienced watery diarrhea and 2 episodes of skin blistering over the elbows, knees, and hands. Results of physical examination revealed muscle wasting and skin hyperpigmentation. The palms had discrete lentigolike macules. The distal fingernails were ragged and nearly absent. The proximal nails were soft and spongy, appearing to be abnormally regenerated nail plates on boggy nail beds (Figure 1). The toenails showed distally adherent plates. There was diffuse scalp alopecia and milia on the elbow where blisters had resolved.