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June 1999

Sodium Benzoate–Induced Acute Leukocytoclastic Vasculitis With Unusual Clinical Appearance

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Arch Dermatol. 1999;135(6):726-727. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-6-dlt0699

Cases of leukocytoclastic vasculitis (LCV) induced by food additives are extremely rare.1-3 We report a case of LCV presenting with purpuric lesions almost exclusively on upper body parts. In this case, none of the common causes of LCV could be found, but double-blind, placebo-controlled oral challenge testing (DPOC) with common food additives revealed sodium benzoate as the causative substance.

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