Enk and Knop1 recently reported in the ARCHIVES the impressive results of treating pemphigus vulgaris with a combination of massive doses of prednisolone and mycophenolate mofetil. Two months after treating a flare in the activity of this disease in 12 patients with this combination of drugs, 9 of the patients were clinically free of disease, and all 9 remained free of disease during the ensuing year. This remission rate is much higher than expected with conventional therapy, which is normally associated with a 10% to 20% remission rate per year.2 From this, the authors conclude that mycophenolate is highly effective in the treatment of pemphigus. But is it?
Bystryn J. Is Mycophenolic Acid Effective for the Treatment of Pemphigus? Arch Dermatol. 1999;135(7):854–855. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-7-dlt0799
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