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July 1999

Is Mycophenolic Acid Effective for the Treatment of Pemphigus?

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Arch Dermatol. 1999;135(7):854-855. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-7-dlt0799

Enk and Knop1 recently reported in the ARCHIVES the impressive results of treating pemphigus vulgaris with a combination of massive doses of prednisolone and mycophenolate mofetil. Two months after treating a flare in the activity of this disease in 12 patients with this combination of drugs, 9 of the patients were clinically free of disease, and all 9 remained free of disease during the ensuing year. This remission rate is much higher than expected with conventional therapy, which is normally associated with a 10% to 20% remission rate per year.2 From this, the authors conclude that mycophenolate is highly effective in the treatment of pemphigus. But is it?

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