Oral photochemotherapy with psoralen (methoxsalen) plus UV-A irradiation (PUVA) and PUVA-bath therapy are highly effective for the treatment of moderate to severe psoriasis. Compared with the commonly used oral application of methoxsalen, bath water delivery has an equal or superior therapeutic efficiency and causes fewer adverse effects than oral delivery, particularly systemic adverse effects, owing to a virtual absence of systemic resorption. In addition, skin photosensitization is considerably shorter compared with that caused by orally administered methoxsalen, and significantly lower doses of UV-A radiation are necessary to clear skin lesions than when using oral PUVA therapy.1,2
Grundmann-Kollmann M, Behrens S, Krähn G, et al. Treatment of Psoriasis With Calcipotriene Plus Psoralen–UV-A–Bath Therapy. Arch Dermatol. 1999;135(7):861–862. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-7-dlt0799
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