A 26-year-old man presented with a 1-month history of penile swelling associated with left inguinal swelling. His chief complaint was fever and malaise, and he was not concerned about the penile lesion. He gave no history of sexually transmitted diseases, said that he was negative for human immunodeficiency virus (HIV) by recent testing, and stated that he had a monogamous relationship with his wife. A workup by his primary care physician for a traumatic penile ulceration 10 months earlier revealed no laboratory evidence of infection (culture negative for herpes simplex virus and a nonreactive rapid plasma reagin test). The patient was treated with a 2-week course of doxycycline.
Gelfand JM, Lee PK, Margolis R, Johnson RA. An Asymptomatic Penile Plaque With Regional Lymphadenopathy. Arch Dermatol. 1999;135(7):845–b–850. doi:10-1001/pubs.Arch Dermatol.-ISSN-8503-987x-135-7-dof0799
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