Clinical observations on the time course of allergic contact dermatitis from urushiol have been made by early investigators.1-3 The onset of the eruption occurs most often within 24 to 48 hours after exposure to the antigen, and rarely as early as 5 to 6 hours or as late as 8 to 15 days. The duration of the reaction is its most variable feature, lasting from days to weeks. Untreated, the eruption can last 3 to 6 weeks.4 These historical observations have not distinguished clearly between previously sensitized subjects and first-time responders. The purpose of this study was to extend these observations by documenting individual variations in the course of experimentally induced allergic contact dermatitis from urushiol in previously sensitized adults.
Williams JV, Light J, Marks JG. Individual Variations in Allergic Contact Dermatitis From Urushiol. Arch Dermatol. 1999;135(8):1002–1003. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-8-dlt0899
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