With great interest I read the review on oral zinc and the healing of leg ulcers by Wilkinson and Hawke.1 I agree with their conclusion that there is limited evidence for using zinc internally unless the patient is truly zinc deficient. We and others have also shown delayed wound healing in animals on zinc-deficient diets.2 The critical issue is to determine whether patients have zinc deficiency. More refined diagnostic criteria together with advanced analytic techniques are becoming available to assess the zinc status more accurately than a single serum zinc measurement.
Ågren MS. Zinc in Wound Repair. Arch Dermatol. 1999;135(10):1273–a–1274. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-135-10-dlt1099
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