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January 2001

Treatment of Cicatricial Pemphigoid With Pulse Intravenous Cyclophosphamide

Arch Dermatol. 2001;137(1):101-102. doi:

Cicatricial pemphigoid (CP) is an autoimmune blistering disease thatinvolves the skin and mucous membranes. The prognosis of the disease dependson its location. Oropharyngeal and ocular locations are particulary severeand very difficult to treat. Dapsone is recommended for patients with high-risklesions.1,2 Unfortunatelysome cases are not controlled by dapsone, or the patient experiences adverseeffects. In these cases a combination of sytemic corticosteroids and an immunosuppressiveagent is required. Oral cyclophosphamide effectively treats pure ocular CP,1,3 and 1 case of successful treatmentwith pulse intravenous cyclophosphamide has also been reported.4Here we report a retrospective study of 9 patients presenting with severeand resistant CP successfully treated with pulse intravenous cyclophosphamide.

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