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January 2001

A Nodule on the Forearm of a Patient With Hodgkin Disease

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Copyright 2001 American Medical Association. All Rights Reserved.Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Dermatol. 2001;137(1):85-90. doi:

Microscopic examination of the cutaneous lesion showed a nodular infiltratewithin the entire dermis, characterized by a dense lymphocytic infiltrateadmixed with small epithelioid granulomas. At higher magnification, histiocytes,epithelioid cells, and multinucleated giant cells could be observed withingranulomatous areas as well as scattered throughout the lymphocytic infiltrate.Round to oval basophilic structures measuring approximately 2 to 4 µmin diameter and corresponding to intracellular amastigotes were observed withinhistiocytes and giant cells. Hodgkin and Reed-Sternberg cells, atypical lymphocytes,and mitoses were not found. Immunohistochemical analysis, performed on paraffinsections using a 3-step immunoperoxidase technique, revealed negative stainingfor CD30 and CD15 and a positive reaction of histiocytes and giant cells forCD68. The lymphoid population was of both B- and T-cell lineage.

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