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February 2001

On the Immunopathogenesis of Psoriasis

Arch Dermatol. 2001;137(2):229-230. doi:

In an interesting article "Response of Murine and Normal Human Skin to Injection of Allogeneic Blood-Derived Psoriatic Immunocytes," Nickoloff et al1 present an innovative idea that immunocytes expressing receptors of natural killer (NK) cells play a possible role in the pathogenesis of psoriasis. The authors suggest that the inhibitory receptors on NK cells (killer cell inhibitory receptors [KIRs]) may prevent NK T-cell–induced lysis of self major histocompatibility complex (MHC) class I–bearing target cells while killer cell activating–receptors (KARs) may activate NK T-cell cytotoxicity and probably contribute to the damage of the epidermal basement membrane in the early stages of disease.

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