Neurofibromatosis type 1 (NF1) develops various neurocutaneous manifestations in patients at various ages.1 It has been suggested that Lisch nodules or pigmented iris hamartomas appear in infancy or early childhood2; however, the frequency of their appearance has been reported to range from 56% to 97% in patients with NF1; there is great discrepancy among these reports.3,4 Since Lisch nodules are usually asymptomatic, little information is available on their clinical behavior.
Otsuka F, Kawashima T, Imakado S, Usuki Y, Hon-mura S. Lisch Nodules and Skin Manifestation in Neurofibromatosis Type 1. Arch Dermatol. 2001;137(2):232–233. doi:
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.