Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001
Plexiform neurofibromas are present in nearly 25% of patients with neurofibromatosis 1 (NF1).1 There have been rare reports of hemorrhages occurring spontaneously or after minimal trauma into plexiform neurofibromas and life-threatening bleeding during surgical excision.2,3 A role has been suggested for increased vascular fragility caused by the NF1-associated arterial dysplasia and by the neurofibromatous venous invasion.4
Wolkenstein P, Mitrofanoff M, Lantieri L, et al. Bleeding: A Complication of Neurofibromatosis 1 Tumors. Arch Dermatol. 2001;137(2):233–234. doi:
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