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February 2001

Bleeding: A Complication of Neurofibromatosis 1 Tumors

Arch Dermatol. 2001;137(2):233-234. doi:

Plexiform neurofibromas are present in nearly 25% of patients with neurofibromatosis 1 (NF1).1 There have been rare reports of hemorrhages occurring spontaneously or after minimal trauma into plexiform neurofibromas and life-threatening bleeding during surgical excision.2,3 A role has been suggested for increased vascular fragility caused by the NF1-associated arterial dysplasia and by the neurofibromatous venous invasion.4