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March 2001

Experimental Contact Sensitivity in Patients With Previous Exposure to High-Dose PUVA Photochemotherapy

Arch Dermatol. 2001;137(3):381-383. doi:

Cell-mediated immunity, assessed by response to dinitrochlorobenzene (DNCB), is diminished in patients with squamous cell carcinoma or dysplasia.1 Responses to DNCB are impaired during psoralen–UV-A photochemotherapy (PUVA), although they are fully restored 6 weeks after treatment.2 High-dose PUVA is associated with the development of lentigines, keratoses, or squamous cell carcinoma in most subjects.3 In this study, DNCB responses were determined in patients previously exposed to high-dose PUVA.

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