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April 2001

Rapidly Enlarging, Violaceous Nodule on the Abdomen

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Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Dermatol. 2001;137(4):495-500. doi:

Sections of the biopsy specimen showed a large, well-circumscribed tumor nodule extending from the reticular dermis to the subcutaneous fat. Connection with the overlying acanthotic epidermis was not identified. The centrally necrotic tumor was composed of nests and cords of highly pleomorphic, poorly differentiated cells with abundant clear to eosinophilic cytoplasm and numerous mitotic figures. Rare gland formation was noted. The tumor stained positively for mucicarmine, cytokeratin, and carcinoembryonic antigen and negatively for vimentin, HMB-45, and S100 protein. The histologic features and staining profile supported the diagnosis of a metastatic poorly differentiated adenocarcinoma, consistent microscopically with the microscopic appearance of the patient's lung cancer.