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June 2001

Delayed EPPER Syndrome

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Dermatol. 2001;137(6):821-822. doi:

Rueda et al1 recently reported that 17% of women receiving radiotherapy for internal cancer developed pruritic eruptions (ie, acral excoriations, erythematous papules, vesicles, and bullae) that favored the lower extremities. Histologically, a superficial and deep perivascular lymphohistiocytic infiltrate with eosinophils was present. These eruptions suggested the denomination eosinophilic, polymorphic, and pruritic eruption associated with radiotherapy (EPPER). We report a case with clinical, histologic, and immunofluorescent findings characteristic of EPPER. In the series reported by Rueda et al,1 the eruptions appeared during radiotherapy. In our case, however, the eruption was delayed by many months.