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August 2001

Pancytopenia After Treatment of Keratoacanthoma by Single Lesional Methotrexate Infiltration

Arch Dermatol. 2001;137(8):1104-1105. doi:

Lesional infiltration with methotrexate for the treatment of keratoacanthoma (KA) has been proposed as a safe, efficient, and cost-effective alternative therapy when size, localization, and patient-related factors contraindicate surgery.1,2 We report a case in which single intralesional methotrexate injection led to severe pancytopenia.

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