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Off-Center Fold
August 2001

A Congenital Midline Nasal Mass in a Newborn

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Dermatol. 2001;137(8):1095-1100. doi:

The biopsy specimen showed an intradermal proliferation of fibrillary neural pil with mature astrocytes, occasional gemistocytic astrocytes, and neurons. The cells stained positively with antibodies to S100 protein. Radiological imaging by computed tomographic scan failed to show any intracranial abnormality.

Congenital nasal anomalies occur once in every 20 000 to 40 000 births.1 The most common are the dermoid, encephalocele, and glioma. Most authors agree that these lesions share a common embryological origin resulting from disordered development of the primitive neural plate. During fetal development, diverticula of dura mater may extend into the prenasal space, forming connections with overlying dermis. Typically, these diverticula will regress. However, if they fail to separate, ectodermal or glial elements may remain, and the nasal and frontal bones may not completely close.2-5