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October 2001

Cytokines May Favor a Role for Human Papillomaviruses in the Pathogenesis of Psoriasis

Arch Dermatol. 2001;137(10):1373. doi:

In the March issue of the ARCHIVES, de Villiers and Ruhland1 reported that the proinflammatory cytokines interleukin 17 and interferon-γ activate in vitro the promoter of human papillomavirus (HPV) 20, a human papillomavirus associated with epidermodysplasia verruciformis (EV), which may induce replication of this virus. They conclude that EV-HPV infection (eg, HPV-5) does not play an active role in the pathogenesis of psoriasis, but that the virus, present latently in the skin, could become activated by cytokines.