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October 2001

A Large Ulcerated Tumor on the Back

Author Affiliations

Copyright 2001 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2001

Arch Dermatol. 2001;137(10):1367-1372. doi:

Hematoxylin-eosin–stained sections showed a hyperproliferation of sebaceous glands in the superficial dermis. The sebaceous glands were moderately to well differentiated, were not uniform in size and shape, and were slightly distorted. Nuclei showed moderate pleomorphism in size and shape. Scattered mitotic nuclei were evident in the sebaceous glands. The tumor was surgically removed and grafted by plastic surgery.

There have been reports of large sebaceous tumors in the literature, but none of the tumors were as large as the one in the case reported herein.1-5 Muir-Torre syndrome was considered in this case;however, because being immunocompromised is a precipitating factor for many internal and skin malignancies,6 it is unlikely that our patient had Muir-Torre syndrome (sebaceous tumors and/or keratoacanthomas with internal malignancy). This case involved giant sebaceous carcinoma in a human immunodeficiency virus–positive person with a history of colon cancer.