[Skip to Content]
[Skip to Content Landing]
November 2001

Molecular Genetics of Heritable Blistering Disorders

Author Affiliations

From the Departments of Dermatology and Cutaneous Biology, and Biochemistry and Molecular Pharmacology, Jefferson Medical College, and Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pa.

Arch Dermatol. 2001;137(11):1458-1461. doi:10.1001/archderm.137.11.1458

Over the past decade, there has been tremendous progress in understanding the genetic basis of different forms of genodermatoses. Specifically, with the advent of technologies in molecular biology in general, an increasingly large number of gene defects have been identified in different genodermatoses, and mutations are now known to occur in more than 100 distinct genes in such a manner that the genetic lesions explain the spectrum of phenotypic manifestations encountered in these diseases.1