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December 2001

Asymptomatic Papules on a Child

Author Affiliations


Arch Dermatol. 2001;137(12):1647-1652. doi:

Routine hematoxylin-eosin–stained slides showed a dome-shaped, umbilicated lesion with a central erosion. Collections of histiocytes and sparse perivascular infiltrates of lymphocytes were present within the dermis directly underlying the erosion. In the deeper aspects of the dermis, there was a rare focus where the histiocytes formed a palisading granuloma.

A therapeutic trial of hydroxychloroquine (6 mg/kg per day) was instituted because of the generalized distribution of the lesions. After 3 months of therapy, all but the lesions on the dorsal aspect of the hand had regressed, leaving only hypopigmentation. The medication was well tolerated, with no adverse effects.

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