IN THE August 2001 issue of the ARCHIVES, Wiseman et al1 presented new and interesting data obtained from a group of 148 consecutive patients who were treated with diphencyprone. The authors provide convincing evidence that this therapeutic modality is associated with a high rate of satisfactory responses that cannot be equaled by any other known treatment.
I agree with the authors that the large range of success rates published in previous studies can be attributed to a lack of uniform definition for "response." Wiseman et al defined a clinically substantial response as "significant regrowth resulting in greater than 75% of the scalp being covered with terminal hair (as determined by the investigators)."
Happle R. Diphencyprone for the Treatment of Alopecia Areata: More Data and New Aspects. Arch Dermatol. 2002;138(1):112–113. doi:10.1001/archderm.138.1.112
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