Mycosis Fungoides: New Insights Into an Old Problem

MYCOSIS FUNGOIDES (MF), as first described by Alibert¹ during the 19th century, is now simply defined as an indolent CD4⁺ non-Hodgkin lymphoma that affects the skin primarily with erythematous patches, plaques, and tumors. Nevertheless, many subtypes of MF have been identified (eg, granulomatous MF,² hyperkeratotic MF,³ hypopigmented MF,⁴ MF associated with follicular mucinosis,⁵ MF bullosa,⁶ MF palmaris et plantaris,⁷ granulomatous slack skin,⁸ and pagetoid reticulosis⁹), each nominally with its own set of clinical and histologic presentations.¹⁰