Chronic and malignant diseases have been shown to affect gonadal hormone secretion.1,2 There are only limited data about endocrinologic changes in male patients with melanoma. Meikle et al3 reported reduced production of testosterone in men with metastatic renal carcinoma or melanoma during therapy with interleukin 2. In contrast, interferon alfa seems to have no effects on the testes of men with hematological diseases or hepatitis C.4
Weidinger SE, Hein R, Ring J, Köhn FM. Endocrinologic Changes in Male Patients With Melanoma During Interferon Alfa-2b Therapy. Arch Dermatol. 2002;138(4):541–542. doi:10.1001/archderm.138.4.533
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