A 49-year-old African American man presented with a 3-month history of 2 slowly enlarging asymptomatic lesions on his scrotum (Figure 1 and Figure 2). Physical examination revealed 2 reddish-yellow, exophytic, pedunculated, verrucous papules, each measuring 7 mm in diameter, on the left and right sides of the scrotum. No other genital lesions were present, and there was no inguinal adenopathy. Serologic tests for syphilis were nonreactive. Biopsy specimens were obtained from shave excisions of both lesions (Figure 3 and Figure 4).