[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
June 2002

Absence of Lisch Nodules in Sporadic Neurofibromatosis Type 1 May Reflect Somatic Mosaicism

Author Affiliations

Not Available

Arch Dermatol. 2002;138(6):839-840. doi:10.1001/archderm.138.6.838

In a previous issue of the ARCHIVES, Otsuka et al1 interestingly reported a higher frequency of Lisch nodules in patients with familial neurofibromatosis type 1 (NF1) than in patients with sporadic NF1. They suggest that there is an increased severity of ocular manifestations in familial NF1 cases. We do not think that an increased frequency of Lisch nodules is correlated with the severity of ophthalmological manifestations of NF1, since Lisch nodules are asymptomatic and not correlated with visual impairment or severe optic nerve involvement.